NGC 5128 is one of the closest radio galaxies to Earth, so its active galactic nucleus has been extensively studied by professional astronomers. The galaxy is also the fifth-brightest in the sky, making it an ideal amateur astronomy target, although the galaxy is only visible from low northern latitudes and the southern hemisphere.

The center of the galaxy contains a supermassive black hole with a mass of 55 million solar masses, which ejects a relativistic jet that is responsible for emissions in the X-ray and radio wavelengths. By taking radio observations of the jet separated by a decade, astronomers have determined that the inner parts of the jet are moving at about half of the speed of light. X-rays are produced farther out as the jet collides with surrounding gases, resulting in the creation of highly energetic particles. The X-ray jets of Centaurus A are thousands of light-years long, while the radio jets are over a million light-years long.

Like other starburst galaxies, a collision is suspected to be responsible for the intense burst of star formation. Models have suggested that Centaurus A was a large elliptical galaxy that collided and merged with a smaller spiral galaxy.