M75 is at a distance of about 67,500 light years away from Earth and on the opposite side of the Galactic Center. Its apparent size on the sky translates to a true radius of some 67 light years. M75 is classified as class I, meaning it is one of the more densely concentrated globular clusters known.

The cluster has a half-light radius of 9.1 ly with a core radius of about 1.6 ly. There are 38 RR Lyrae variable stars and the cluster appears to be Oosterhoff-intermediate in terms of metallicity. 62 candidate blue stragglers have been identified in the cluster field, with 60% being in the core region.

Messier 75 is part of the Gaia Sausage, the hypothesized remains of a dwarf galaxy that merged with the Milky Way. It is a halo object with an orbital period of 0.4 Gyr around the galaxy and a large eccentricity of 0.87.